As you slide more elements, the others will be eliminated and the others will be rolled softly Upon use, this item summons a ghost near Isaac that will follow him around. Touching the white flame temporarily turns you into The Lost, but allows you to walk through the mirror into a mirrored version of this floor. The room doors will open if only frozen enemies remain, UNLOCK: Unlock this trinket by defeating challenge #41 (Pica Run), Every time you kill an enemy you get an invincibility shield for 1 second, While shielded, each enemy killed adds +1 seconds to the duration, UNLOCK: Unlock this trinket by defeating challenge #37 (Bloody Mary), * item room, treasure room, item room pool, green, cry, plant, Tears now shoot three at a time (Triple Shot). Glass Cannon allows you to fire one huge spectral tear that deals a lot of damage. ?s soul, blue baby's soul, blue babys soul, When you kill an enemy, you have a chance to get +0.5 damage up for the current room, UNLOCK: Unlock this item by beating the Dark Room with Samson, *, hair, pony, tail, brown, red, samsons lock, Gives a 25% chance to reveal map icons at the start of a new floor (The same effect as the Compass), UNLOCK: Unlock this item by beating the Chest with Cain, When you kill an enemy, you have a chance to spawn a transparent Dead Bird familiar, The Dead Bird familiar deals 2 damage per tick to enemies while in contact with them, UNLOCK: Unlock this item by beating the Isaac boss with Eve, *, grey, gray, black, striped, eves bird foot, REPENTANCE - No longer replaces chests that have already spawned, UNLOCK: Unlock this item by beating Ultra Pride, * northernlion, drop the left hand, paw, bloody, bleeding, grey, gray, While held, tinted rocks and rocks with a crawlspace below them will flash white every 10 seconds, *, grey, gray, silver, lump, metal, stone, Turns all troll bombs into bombs which you can pick up and use, Super Troll bombs turn into 1+1 free double bomb pickups, Gives your tears a random worm effect every few seconds, The possible tear effects include: Whip Worm, Ring Worm, Wiggle Worm, Flat Worm, Hook Worm, Pulse Worm, Tape Worm and Lazy Worm, While held, Tape Worm doubles your range stat and halves your tear height stat, Every time you get hit, you have a chance to activate the D6, D20, D8, D10 or D12 effect. Guide to Unlock Marbles Step 1: Unlock Tainted Cain (Spoilers) If you haven't yet, you'll need to unlock Tainted Cain. Pressing it again allows you to throw it at enemies. The Planetarium is a special rare Item Room that is more likely to appear whenever you don't enter an Item Room in a previous floor. This allows Isaac to potentially accrue a large number of stat upgrades. Holy Light: Holy tears are a great source of extra damage. Holding this trinket increase that chance by +15%. This effect can't be abused - next time it will be empty if dropped, UNLOCK: Unlock this trinket by defeating Mother as Tainted Magdalene, Every 15 shots you will shoot an Ipecac + My Reflection shot, The tear will fly in the air for about 3 seconds and follows Isaac until it falls and explodes. The size resets when leaving the floor, UNLOCK: Unlock this item by defeating The Beast as Tainted Lazarus, A fetus familiar follows Isaac, and upon entering the Boss room on each floor, it will transform into a copy of the boss, This makes bosses a lot harder, however you now get 2 boss item drops, UNLOCK: Unlock this item by defeating Hush as Jacob & Esau, You gain two familiar demons, that stay by Isaac's side and fire shots in the same direction as you, The familiars deal roughly 40% of Isaac's damage, scaling with damage upgrades you get, They sit near and rotate around Isaac depending on which way you're firing tears. It can take you to rooms that require bombs/keys, e.g. This is to prevent a syngery like Dr. Fetus or a Golden Bomb giving you infinite resources, Isaac's shadow will follow closely behind him and when it comes into contact with enemies, will spawn friendly dark charger mobs, The chargers deal contact damage to enemies, and will be killed if it is hurt too much, Chargers disappear upon entering a new room, UNLOCK: Unlock this item by beating Greed Mode with Judas, Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20, Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies, A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each, Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage, After being spilt, the milk gives you a -2 Tear Delay (Tears up) for the rest of the room, When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room, Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need, This item has no effect in Greed Mode, Challenge Rooms and rooms that had no enemies in originally, If used in a Boss Room or Angel/Devil Room, you get teleported to another random room, which is reset instead of the boss/angel/devil room you were in, Enemies respawned by the D7 don't drop loot if they were champions and also don't grant score in daily runs, * dice, pip, die, turban, white, grey, gray, Makes Isaac very small like a baby, reducing his hitbox size, When used, Mom's Box will drop a random trinket on the ground, While held, doubles the effect of trinkets which make sense to be doubled (e.g. The door can only be opened if you have The Polaroid, The Negative or Faded Polaroid (the item/trinket is taken away when it opens). ?, Satan and The Lamb as Tainted Lost. After a few seconds, the crosshair will disappear, and the Ghost will do certain things based on what you targeted: Items, pickups, trinkets: Brings them to Isaac. - Spawns one blue attack spider for every enemy in the room. - When used will consume your current trinket, destroying it and giving you its effect permanently. The mirrored floor rooms have respawned enemies, and allows you to optionally fight the Boss a second time for an extra item, When combined with Knife Piece 2, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, Combine with Knife Piece 1 to create a Knife which can be fired across the room, dealing 25 damage to any enemies it comes into contact with, In the Mines/Ashpit II, there's a room with a minecart and a broken track. You can pick which dice you want to use. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. The Crane Game pool has really good items on average, with items like Tech X, Cricket's Head, Small Rock, the D6, and many more. While firing tears the water will be fired as a projectile across the room. ?, Satan and The Lamb as Tainted Isaac, Every time you enter a brand new room, you have a chance to get a random one-time use Dice (e.g. hearts, keys, bombs, coins, pills, cards, trinkets, batteries etc, After the first drop, he has a 67% chance to drop a pickup after 3 coins and a 33% chance to drop a pickup after 4 coins, Bum friend also has a chance to spawn items from the Beggar Item Pool, Counts as 1 of 3 bum items needed towards the Super Bum transformation, * item room, treasure room, item room pool, baby, pink, Item Pool: Devil Room, Curse Room, Red Chest, Gold/Stone Chest, * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal, dead, cat, grey, gray, guppy head, guppys head, Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Using it with less than 5 coins does nothing, UNLOCK: Unlock this item by collecting 99 coins then spending all of them in the same run, Item Pool: Item Room, Greed Mode Item Room, Upon use, grants use of Brimstone for the current room, If used twice in the same room, the brimstone laser becomes massive and deals +1.8 more damage, Using it more than twice in the same room will give a damage increase each time. Function: Gives Flight, +2 Soul Hearts, Holding down the fire button for 2.35 seconds charges a beam that deals 15 ticks of your tear damage, Unlock Condition: Defeat Mother as Bethany. ), UNLOCK: Unlock this item by defeating The Beast as Tainted Eden, *, tm trainer, glitched items, glitch item, tmt trainer, tmelt, t melt, When used, it puts the closes enemy in chains for 5 seconds, preventing it from moving. See previous icon for normal character effects, Tainted Isaac - Adds 4 more spaces for passive items, Tainted Maggy - Adds 1 extra real heart container that doesn't deplete, Tainted Cain - Doubles picks dropped when touching an item, Tainted Judas - Increases the range in which Dark Arts hits enemies and tears, Tainted ??? This includes key blocks and secret room doors, +1.0 Damage Up, but each rock tear has a random damage modifier that can go up or down (x0.5 to x2), Allows Isaac to charge by double tapping the same direction, dealing damage to any enemies caught, You are invincible while charging (doesn't include self-damage like Blood Donation machines), The dash deals x4 your current tear damage + 8, Doesn't have to be in a straight line, you can hold another button to curve it, Has a 3 second cooldown before it can be used again, While not moving your speed rapidly increases up to a bonus of +0.5, While you have this +0.5 bonus, moving will cause Isaac to fart around the room, spawning poison gas clouds, The farts stop spawning once you reach your regular movement speed, Poison deals damage equal to half your tears per tick, Isaac is immune to Poison from enemies, such as Gasbag, Gives you a wide circle halo which grants 7 orbital tears upon entering a new room, The tears orbit for 13 seconds before dropping off, Has a chance to absorb any enemy tears and add them to the orbiting tears. When the effect wears off, Isaac quickly runs between each marked enemy, dealing high damage to each one rapidly (roughly x2.5 your tear damage), The damage caused by this effect scales up with every target it hits in a row, UNLOCK: Unlock this item by defeating Delirium as Tainted Judas, *, budas, jubas, sword, blood, omae wa mou shindeiru, When used, Abyss consumes all pedestal items in the current room and converts them into Red attack flies, Red attack flies will charge across the room in the same direction Isaac is shooting, dealing contact damage to enemies equal to Isaac's tear damage, The flies don't block enemy shots, but this also means they never die and stay with Isaac forever, UNLOCK: Unlock this item by defeating Delirium as Tainted Apollyon, Staples one of Isaac's eyes shut, meaning he only shoots tears from one eye. Based loosely on the Steam Workshop mod created by Extreme Ninja Home Makeover with changes by Edmund McMillen, *, lepracy, leprasy, leprosy, pink, red, bloody, lump, Gives you a random Harbinger familiar that changes every 10 seconds, Each harbinger behaves differently, based on any of the original 5 horsemen bosses, REPENTANCE - The harbingers will also randomly spawn their relevant Locust variant. ?, Satan and The Lamb as Tainted Blue Baby, Drops 2 bombs at once (only 1 bomb is removed from your total), UNLOCK: Unlock this trinket by defeating Mother as Tainted Blue Baby. Every 40 seconds spent in the same room since last activating, when the timer displays 00, 20 or 40 seconds, a shield triggers, nullifying all types of damage for 10 seconds, As soon as Isaac has half a red heart or more, this item deactivates, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Lazarus, While firing tears this item gives you a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac, The evil eye shots will be destroyed if they come into contact with enemies or obstacles, UNLOCK: Unlock this item by beating Greed Mode with Cain, Each time Isaac kills an enemy, you get a temporary +0.5 damage up which lasts for the current room, Each subsequent kill will stack further damage up to a maximum of +5 Damage Up after 10 kills, This item is the same principle as the Bloody Lust item from the original flash game, REPENTANCE - Added to the Devil Room pool, UNLOCK: Unlock this item by beating Greed Mode with Samson, Item Pool: Item Room, Devil Room, Greed Mode Item Room, After taking enough damage you will gain a permanent demon familiar, Possible familiars include: Dark Bum, Demon Baby, Leech, Lil' Brimstone, Succubus, Incubus, Lil Abaddon, Twisted Pair. When taking damage, the cannon will break and remain broken until recharged (Recharge time: 4 rooms). UNLOCK: Unlock this card by opening Mom's Box on the Home floor. Subscribe. Once you have this key, you can then unlock the two characters. Explosion damage has increased to 100 (from 60). Based on the Steam Workshop mod created by Amethyst, UNLOCK: Unlock this item by using 5 Gulp! Mulligan can be hit by enemy projectiles, making him a good shield, Enemies will sometimes target the Mulligan if he is closer, * item room, treasure room, item room pool, sad, baby, lumpy, brown, pink, When used, makes Isaac leap in the air, similar to the leaper enemies, Maintains momentum if you are already moving in the same direction, If you already have an item which gives you flying, this item becomes a dash effect instead, Can be used in the Isaac boss fight to jump over the beams of light he spawns, * library pool, library room, book room pool, item room, treasure room, item room pool, Holding the fire button charges a spin attack (Damage * 8 + 10). After killing a 15 enemies, Blood Puppy transforms into an aggressive version that will also attack Isaac by charging at him. When used, this will combine with your other active item, creating a unique flame and possibly giving special effects, The recharge time of this item is based on your 2nd active item, otherwise it's 4 rooms, While held, guarantees the first Devil/Angel Room encountered to be an Angel Room, and increases the overall chance of getting one, A maximum of 16 flames can be active at one time around Isaac, Counts as 1 of 3 book items needed towards the Bookworm transformation, UNLOCK: Unlock this item by defeating Isaac as Bethany, A single use active item that will spawn 3 soul hearts and 2 items from the Angel Room pool, Starts fully uncharged and gains charges only through picking up soul and black. The Red Key item is required to access it, but it shows the direction to get there, UNLOCK: Unlock this item by defeating The Beast as Eve, Upon entering each new floor, if you have one red heart or less, another one is added, This effect works while moving up floors in the backwards path, This item has no effect for characters with non-red health i.e. ?, Satan and The Lamb as Tainted Azazel, When entering a new room, gives a small chance to gain Azazel's short-range Brimstone laser for the current room and the ability to fly, UNLOCK: Unlock this trinket by defeating Mother as Tainted Azazel, Spawns 2 friendly Dips upon clearing a room, Dips that spawn after killing a Squirt turn friendly, UNLOCK: Unlock this trinket by defeating Isaac, ?? when entering the item room, Gives +1 Soul Heart when starting each new floor after picking this up, Currently this effect doesn't work in Greed Mode - It will show 2 items but the item rooms will have different items in them, Gives +0.4 Tears Up for each room completed without taking damage, up to a maximum of +2.0 Tears Up, When you take damage, the tears bonus is reset, Picking this item up counts and gives you a temporary +0.4 Tears Up as well, Allows you to double-tap the shoot button to create a holy shield for 1 second that pushes enemies back and deals 10 damage to them if they touch it, The shield also reflects enemy shots and beams back at them for some extra damage, Can only be activated every 3 seconds (Shown by a white glow and a ticking noise). You must make it back through the path solving a few bomb puzzles while avoiding her, to get back to the regular floor. Health down effects still only remove 1 heart, Eve - Whore of Babylon and Dead Bird effects are always active, Samson - Bloody Lust can gain 4 more damage boosts, for a new max total of +14 Damage, Azazel - His beam becomes much wider, no effect on damage. Counts as 1 of 3 book items needed towards the Bookworm transformation. A familiar baby that fires tears which have a chance to freeze or petrify enemies, Counts as 1 of 3 familiar items needed towards the Conjoined transformation, When used, rerolls all items in the room into another random item from the current room's item pool, however the item also has a 30% chance to disappear, The chance associated with this item does NOT scale with your Luck stat - it's always 30%, In the game files this item is called 'Florians Dice', which is a reference to the Eternal update for the original Binding of Isaac game, which changed the D6 to act as this item does. Everything is sold for its shop price, e.g. *, brown, red, tup, carton, box, golden chest pool, gold chest pool, Item Pool: Boss Room, Gold/Stone Chest, Mom's Chest, *, white, necklace, grey, gray, moms pearls, mom pearls, The Car Battery causes your spacebar item to activate twice on each use, For example, with Yum Heart you would heal 2 full red hearts instead of 1, Upon use, gives you a duplicate of each familiar you have for the current room, It will not 'double' your familiars as the tagline suggests - if you have 2 of one kind, it will only give you an extra one, If the familiar only appears when taking damage (i.e. Poison deals 5 damage initially and then 3.5, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Isaac, REPENTANCE - GB Bug is now a thrown projectile, activated by double tapping an attack button. Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost', If held when you touch the chest after the Satan or Isaac fight and you don't have the relevant item to go to the next floor (Polaroid or Negative), you have a small chance to be taken there anyway, UNLOCK: Unlock this item by beating the Chest with Eden, 80% of heart drops are replaced with keys, Hearts turn into black hearts where possible. Time is the essence", "Sleeping gatekeepers will need to be awoken with a loud sound", UNLOCK: Unlock this card by beating Challenge #11 (Glass Cannon). It stops moving while Isaac is firing tears and upon releasing the fire button, King Baby will teleport back to your location, King Baby will always appear first in the queue of familiars, REPENTANCE - Familiars now automatically aim at enemies when being commanded by King Baby. ?, Satan and The Lamb as Tainted Apollyon, Gives you a red attack fly, that will charge at enemies in the same direction you are shooting, Deals damage equal to your current tear damage, Stops charging once it hits an enemy and returns to Isaac's side, UNLOCK: Unlock this trinket by defeating Mother as Tainted Apollyon, Gives a 33% chance to spawn an extra blind pedestal item in all future item rooms. With Keeper's buff of an additional Coin Heart, unlocking this item isn't that difficult compared to what it would have been in AB+. Spoon Bender, Telepathy for Dummies, I - The Magician), While held, gives you a small chance to gain a bone heart everytime you take damage, REPENTANCE - Finger Bone's chance to grant a bone heart has been increased to 5% per hit taken (from 2%), UNLOCK: Unlock this trinket by defeating Ultra Greed as The Forgotten, Teleports the player to the first room of the current floor, There is a guaranteed Fool card in the Depths 2, if you bomb the skull with an X on it. Also summons a blue crosshair which can be moved around freely. Spoilers of course for Repentance mechanics and unlock conditions. This tear turns enemies to gold for a few seconds and causes them to drop 1-4 coins if killed while golden (similar to the Midas' Touch item), When the Midas Touch tear effect triggers, it will remove 1 coin from your current total, The golden tear deals double your tear damage, The effect can still trigger even if you have no held coins, UNLOCK: Unlock this item by defeating Greedier Mode with Keeper, Doubles the effect of most tarot cards. * item room, treasure room, item room pool, white, purple, Gives Isaac the ability to fly and spectral tears, * devil pool, devil room pool, devil deal, red, crescent, moon, drop, black, Creates 5 beams of light from the sky that deal damage equal to your tear damage + 20 to any enemies which come into contact with them, The beams have a high chance to spawn on top of enemies where possible, * item room, treasure room, item room pool, feather, white, arrow, Upon death, you respawn in the previous room as Blue Baby with three Soul hearts, This is a one time use item and all new heart containers will be soul hearts, Can be used to unlock some of Blue Baby's secrets before having the character available, * item room, treasure room, item room pool, black, grey, gray, extra life, egypt, grey, gray, Upon taking damage, you have a 20% chance to gain an invulnerability shield for 7 seconds, The chance to gain a shield is affected by your luck stat and at +27 Luck it will activate every time, UNLOCK: Unlock this item by beating the Chest with Maggy, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, - When used, shoots an Ipecac explosive shot. Flies spawned from a Mulligan dying, When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing, The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times, The spike wave will deal 10 damage to any enemies in contact with it. the eternal hearts that drop in angel themed super secret rooms, All heart drops from Ace of Hearts will be Black Hearts, UNLOCK: Unlock this item by beating Satan with Azazel, *, black, devil, pointy, daemons tail, demons tail, demon tail, Dying in a sacrifice room while holding this trinket will unlock The Lost character, After The Lost is unlocked, dying anywhere with this trinket will bring you back to life as The Lost and the trinket will be deleted, When playing as Tainted Lost, you don't swap to being regular Lost, it simply acts as an extra life, UNLOCK: Unlock this item by beating Dark Room with Isaac, Everytime you pick up a coin, you fart, inflicting poison damage to nearby enemies, Greatly increases the chance of coins dropping from poops, Tears now move forwards at right angles, shifting left and right across the room, Increases your range stat by +10.0 while held but due to the fire pattern, your tears travel a similar distance to normal, Your tears now whip across the room at a very high shot speed, Shot speed gives your tears more effective range, but doesn't increase your range stat directly, Has a 22.22% chance to respawn with 3 Soul hearts as Blue Baby when you die, UNLOCK: Unlock this item by beating Satan with Lazarus, Everytime Isaac takes damage, one blue fly will spawn, * , the lost item pool, green, red, bloody, dead, Isaac's tears have a chance to poison enemies, The poison effect leaves a damage over time, which deals 4 or 6 damage per tick, The chance to poison enemies is affected by your luck stat and at +18 Luck it will activate every time, Isaac now has a chance to make a spectral and piercing tear, The chance to fire a piercing tear is affected by your luck stat and at +18 Luck it will activate every time, While held, this trinket gives a random mushroom effect each room, Possible mushrooms include: Mini Mush, Odd Mushroom (Thin), Odd Mushroom (Thick), The Compass, *, ping, pong, paddle, grey, gray, mushroom, While at 1/2 a red heart of health, you gain a Little Steve familiar that follows you and shoots homing tears, REPENTANCE - Umbilical Cord now has a high chance to spawn a Gemini familiar for the room when Isaac takes damage. the lost item pool, red, beads, grey, gray, cross, necklace, An orbital which blocks shots and damages enemies it comes into contact with for 7 damage per tick, Exclusively drops from one of the horsemen bosses, 2 cubes of meat transform the orbital into a meat head which fires blood tears which deal 3.5 damage each, 3 cubes of meat transform it into a meat boy familiar that walks around and deals 3.5 contact damage per tick to enemies, 4 cubes of meat cause the meat boy familiar to grow in size and do 5.5 damage per tick instead, Any further cubes of meat past 4 will start the cycle again, UNLOCK: Unlock this item by beating Mom for the first time, Has a very small chance to drop after destroying one of the pots that appear in the Basement and Cellar floors, Has a chance to drop from the Super Greed miniboss fight, UNLOCK: Unlock this item by beating Mom's Heart 8 times, Item Pool: Devil Room, Gold Chest, Super Greed Miniboss. in an Angel room, this will spawn 2 Angel room items), Starts with 0 charge and requires 12 charges to use, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Eden, Every 6-7 rooms Acid Baby will drop a random pill, Every time you use a pill, Acid Baby will deal 10 damage to all enemies and poison them for 6-7 ticks, REPENTANCE - Poison effect is stronger, but Acid Baby's pill drop rate has been reduced to every 6-7 rooms (previously every 2-3 rooms), A familiar fairy that will float around the room and highlight the location of any secret room doors, tinted rocks or trapdoors under rocks, Upon entering a new room, if there is an undiscovered secret room or tinted rock, it will move directly to the point of interest, otherwise it will just randomly fly around the room, For every empty red heart container, Isaac gains Damage Up and his body increases in size, Only works on full hearts - damage does not change if Isaac is missing 1/2 of a heart in one container, Healing empty red heart containers will remove the damage increases, Has no effect for The Lost and ?? 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